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Knowledge of the precise interactions of a given protein is crucial for the understanding of its functions.
Knowledge of the precise locations of nucleosomes in the genome is thus essential towards understanding how transcription is regulated.
Any such structure-guided effort would require the knowledge of the precise mechanism of NAD+ recognition by the enzyme.
Although the correction terms are typically small, knowledge of the precise subtleties of the fine structure might be critical in terms of comprehending many new nanoscale phenomena.
The students have no prior knowledge of the precise content of the competitions, and are given only a broad syllabus of theoretical, experimental and mathematical skills they should revise.
They dispatched a man to the Netherlands in April 1604 to enlist Fawkes, who, without knowledge of the precise details of the plot, returned to England and joined them.
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However, the assessment of the physiological relevance and therapeutic potential of the CB1 receptor in neurological diseases is hampered, at least in part, by the lack of knowledge on the precise molecular mechanisms of CB1 receptor neuroprotective activity.
However, there is a surprising lack of knowledge on the precise functional roles played by many animals within soils.
40 41 In our calculations, this effect was not assumed since there is lack of knowledge on the precise association between cyclist numbers and accident risk.
This mapping can hardly be generally applicable to any graphical formalism but requires precise knowledge of the exact semantics of the graphical language.
Subjected to elaborate investigation and a sumptuous publication of results, the increase of knowledge and the precise measurement of effects, which had only been recognised in a qualitative and even uncertain way, was very largely instrumental in inspiring a change in our outlook on the fundamental principles of both the old and the new seismology.
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