The knowledge of the subcellular localization of a SNARE of interest is essential to understand its function.
The coarse-grained (CG) force field is hierarchically decomposed at different resolution levels enabling to choose the most appropriate wavelet family for each physical interaction without requiring an a priori knowledge of the details localization.
Knowledge of the subcellular localization of proteins can provide important insights into protein function and thus is particularly useful in the annotation of genomes and the identification of candidate proteins having functions of interest.
Dear Editor, Deciphering the role of any protein in a cell requires knowledge of the structure, subcellular localization, and the topological orientation of the protein within the relevant cells.
Here we provide the first evidence, to our knowledge, showing the localization of GluR2 in VTA dopamine neurons, instead of GABA neurons.
The effective use of ribozymes in vivo depends on effective target-site selection, knowledge of the rules governing intracellular localization, effective delivery to target cells, and maintaining a high and long-term intracellular expression of the engineered gene.
Current knowledge of the importance of tumor localization (ET versusVR tumors) when it comes to the prognostic impact of angiogenic markers in STSs is limited.
This is achieved by employing coordination and trajectory following techniques, and the knowledge derived by the localization of the robots from their environments.
It could be hypothesized, however, that the most reliable blood-derived biomarker could be found based on lung tissue analyses with the knowledge of cell-specific localization and with an established association with the course and the phenotype of the disease.
Tomer Shlomi (Technion University, Israel) also showed that reconstructing a model may involve further challenges, pertaining for instance to the proper account of cellular compartments in absence of prior knowledge of enzyme localization.
