Sentence examples for knowledge of protein evolution from inspiring English sources

Interchange probability is a numerical measure of the incidence of a disease in terms of knowledge of protein evolution.

In any case such improved models would be helpful to advance our knowledge of protein evolution, since in most cases one can select a set of species for whose relationships are confidently known, which drastically simplifies the problem and allows the use of complex but computationally demanding models.

However, to the best of our knowledge, the MDS projection technique has never been applied previously to the field of protein evolution.

Fig. 3 The "jackprot" model of protein evolution.

We do so by incorporating a priori knowledge of protein structure, evolution and interaction, and cellular signaling and regulatory pathways.

Diverse multi-domain proteins may consist of homologous domains and knowledge of protein domain evolution may considerably help in reconstructing the evolutionary history of entire proteins.

Knowledge of protein structure, dynamics, enzyme mechanisms, and natural evolution demonstrates that multiple (combinatorial) mutations are required to discover the most improved variants.

For example, the McDonald-Kreitman test [10], which uses contrasts of polymorphic and fixed variants to test the neutral model of molecular evolution, requires no knowledge of protein structure or specific functions of residues or domains.

Comprehensive knowledge of protein-ligand interactions should provide a useful basis for annotating protein functions, studying protein evolution, engineering enzymatic activity, and designing drugs.

The evolution of such sequences, however, does show many attributes of real protein evolution.

Clearly, there is a twilight zone for TM helices with intermediate z-scores which are difficult to classify without a priori knowledge of the protein's evolution and function.