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In contrast, IBS can be calculated without knowledge of pedigree structure and does not require allele frequency information.
We proposed an extension to the GRAMMAR method [11], which increases its' power, maintains a nominal type 1 error and also does not require the precise knowledge of pedigree structure.
To conclude, GRAMMAR-GC is a fast powerful approach for genome-wide association analysis of quantitative traits in samples of related individuals, which does not require precise knowledge of pedigree structure.
The result in Figure 5 shows that the knowledge of pedigree structure is indispensable in solving the genome ancestry problem.
To interpret whole exome/genome sequence data for clinical and research purposes, comprehensive phenotypic information, knowledge of pedigree structure, and results of previous clinical testing are essential.
Collection and collation of comprehensive phenotypic information, knowledge of pedigree structure, and clinical testing results are necessary to optimize the application of whole exome and whole genome sequence approaches to explain human phenotypes.
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O'Brien's knowledge of pedigrees and bloodlines was unsurpassed.
The first selection stage is based on knowledge of the pedigree with the aim of selecting horses suitable for CG test (at 3 years old) and CJ test (at 5 years old).
In the proposed approach, knowledge of flock pedigree is assumed perfect; the model can however be easily modified to take into account incomplete or imprecise knowledge of flock pedigree.
Interpretation of the accuracy of gEBV without knowledge of the pedigree relationships within the population is not optimal.
The choice of the best model for the sampling method depends on the size of the analyses and the knowledge of the pedigree.
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