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Further integration of multiple 'omics' datasets through advances in bioinformatics tools will increase our knowledge of pathway architecture and regulation at an ever-increasing rate.
Our increasing knowledge of pathway conservation facilitates the use of nontraditional species as toxicological models.
New versions of the in silico model would include the simulation of persistor bacteria, intracellular bacteria, etc., depending on the availability of biochemical knowledge of pathway behavior under these conditions.
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Knowledge of pathways linking interpersonal violence exposure to recurrent headache could help guide prevention and tailor intervention.
Statistical association-based models do not depend on prior knowledge of pathways and instead use correlations and patterns in experimental data to predict network structure.
Again, the method does not make use of the structure of the network, nor does it provide a systemic account for the combined knowledge of pathways to reduce to an optimal set of classifying processes.
Expansion of our knowledge of pathways will contribute to better E. coli metabolic engineering.
Thus, the list of reactions can be mapped to existing knowledge of pathways.
With comprehensive knowledge of pathways and mammalian biology, we can greatly reduce the hypothesis space.
A putative draft of TCR signalling pathways based on knowledge of pathways known in mammals was constructed.
The combined knowledge of pathways and regulators of gene transcripts may deepen the understanding of biological mechanisms in metastasis.
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