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Detailed knowledge of functions of σ factors is a prerequisite for their engineering aimed at modulation of transcriptional regulatory network and, consequently, strain improvement for biotechnological purposes (Tripathi et al. 2014).
We remark that the knowledge of functions a ijx, b ihx and d is not necessary at all: the previous conclusions can be easily derived by the qualitative information that d21 is strictly decreasing and asymptotically converging to 0, while b11 x1, b22 x2,, a32 x2 and b33 x3 are increasing.
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Comparative genome analysis of related species provided a powerful and general approach for identifying functional elements without previous knowledge of function [ 16, 17].
Or he could have said that ontological neutrality about structure and composition is compatible with knowledge of function.
Many human genome scientists opposed the policy of granting gene patents without knowledge of function, whether for ESTs and cDNAs or complete gene sequences.
Programmers who are particularly concerned with the runtime performance of their programs can apply the knowledge of function call overheads to their program design and use modern compilers that combine efficient local optimization with automatic in-lining capabilities.
Knowledge of function is critical for selecting objects to meet action goals, even when the affordances of those objects are not mechanical for instance, both a painting and a vase can decorate a room.
The approach in this classification is simply to look for statistically significant patterns without any knowledge of function.
However, for some families pleiotropy and a lack of knowledge of function across a broad taxonomic base makes it difficult to unambiguously infer ancestral function.
Complete knowledge of function would aid in the prioritization of loci when searching for the genetic bases of disease or adaptive phenotypes.
This approach is unbiased and does not depend upon prior knowledge of function or presumptive involvement of any gene in disease causation.
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