The topics ranged from every day life in Nazi Germany, to knowledge of concentration camps, attitudes towards Hitler, and the war itself.
Therefore, these methods are insufficient for the study of anti-cancer drug kinetics, which requires knowledge of concentration in deep tissue where tumors occur, and can only be measured in vivo.
For proper design and operation of NF for selective removal of sulfate from seawater and the like of saline streams, knowledge of ions concentrations at the membrane surface and on the concentrate side of the membrane is critical.
Without knowledge of plasma concentrations, which reflect the pharmacokinetics of the drug, a comparison with human therapeutic concentrations cannot be made and incorrect conclusions could be drawn regarding the exposure concentration at which a pharmaceutical elicits a response, and thereby incorrectly estimating the threat to non-target organisms if the drug is present in the environment.
Boundary conditions at inlet and outlet require knowledge of the concentrations in the reservoirs.
The metabolic engineering requires detailed knowledge of the concentrations and flux rates of metabolites and metabolic intermediates in vivo.
Lab-On-a-Chip (LOC) technology exploits the progresses in microfluidics, enjoying very fast transport times and accurate knowledge of molecular concentrations.
Specifically, tight binding of T to SHBG is believed to render the SHBG-bound T fraction biologically unavailable, meaning that interpretation of T levels in the clinical setting depends in part on knowledge of SHBG concentrations.
Using these equations and knowledge of the concentrations of reagents, the times of interactions, and the on- and off-rates of the molecular interactions for each step of the assay, it is possible to predict the number of immunocomplexes that are formed and detected by SiMoA.
