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At Bayer Healthcare, Pierce also sees growing applications of structure-function knowledge of compounds and targets.
The knowledge of compounds present obtained by SPME allowed elucidation of the most probable sources assigned to ions measured by the PTR-MS.
John Giesy, now the holder of a Canada Research Chair in Environmental Toxicology at the University of Saskatchewan and the researcher who first reported PFCs in the environment, was with Michigan State University in 1997 when 3M asked him to offer opinions on the state of the knowledge of compounds produced by the company.
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Current knowledge of compound properties that govern transporter effects of bRo5 drugs is limited and requires further fundamental and comprehensive studies.
"I admire Buffett for his expertise in stock investing and his knowledge of compound interest, which makes him one of the richest men in the world.
Unlike existing methods such as the chemogenomic approach, the transcriptomic approach enabled the prediction of target proteins without dependence on prior knowledge of compound chemical structures.
The results demonstrate that it is possible to detect potential contaminants and, in general, non-targeted compounds in complex samples without prior knowledge of which compounds are present.
In this study, we developed a scoring function for the identification of the active compounds in the AuPosSOM clustered dataset without prior knowledge of the compounds' activity.
Traditionally, this has meant a mix of good old-fashioned intuition, a vast knowledge of different compounds, and lots of chemical ingenuity.
Computer-aided drug design (CADD) and, in particular, ligand-based drug design provide a myriad of tools to identify rapidly new chemical entities for modulating a target based on previous knowledge of active compounds without relying on a ligand complex.
A heavy-smoking, baseball-capped Iowan, Talley has an encyclopedic knowledge of chemical compounds.
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