Sentence examples for knowledge of alterations from inspiring English sources

However, knowledge of alterations in signaling pathways underlying BPA's deleterious effects is incomplete.

Development of acquired resistance against antiestrogen treatment is a serious problem in human breast cancer, and knowledge of alterations resulting in resistance is important for selection of further treatment.

In this study we aimed to further increase the knowledge of alterations to the bronchoalveolar system induced by occupational exposure to GRP and to clarify the pathogenic mechanisms involved.

Comparative genomic hybridization (CGH) has contributed significantly to the current knowledge of genomic alterations in hematologic malignancies.

The discovery of effective pharmacological interventions that can prevent the development of epilepsy requires knowledge of the alterations that occur during epileptogenesis in brain regions that play a central role in the induction and expression of epilepsy.

Xenotransplantation models enable the propagation and analysis of primary human samples but may be difficult to interpret due to variability of genetic background, the effects of immune recognition, a limited knowledge of genetic alterations in samples before and after xenotransplantation, and incomplete interaction with the microenvironment.

The knowledge of molecular alterations may help achieve this.

The purpose of this study is to increase knowledge of HSPG alterations in breast cancer.

Detailed knowledge of epigenetic alterations and associated molecular mechanisms during pancreatic tumorigenesis and metastasis will broaden the biological understanding of the disease and help devise novel targets for earlier diagnosis and increasingly effective therapies.

The aim of the work was to increase our knowledge of structural alterations of HSPGs in breast cancer, which could be of future benefit in the development of new chemical biology approaches to the retarding of tumor progression through the modulation of deregulated biosynthetic pathways.

In summary, a better knowledge of miRNA alteration in such cases can potentially provide new markers to improve diagnosis and prognosis, as well as novel therapeutic approaches for BL treatment.