Suggestions(1)
Exact(7)
Baseline assessments and randomisation will be conducted prior to knowledge of allocation.
Interviewers were given a scripted interview to minimize any bias in the assessment due to knowledge of allocation.
The trials statistician will have access to unblinded data, but will prepare results without knowledge of allocation to randomization coding.
To reduce bias from knowledge of allocation, recruitment was attempted before revealing the centre allocation and was achieved for 213 patients (30.7%).
Knowledge of allocation was adequately concealed in nearly all studies (7/8), whereas an adequate concealment of the allocation was reported in only four of the studies.
1: allocation sequence adequately generated; 2: allocation adequately concealed; 3: knowledge of allocation adequately prevented; 4: incomplete outcome adequately addressed; 5: free of selective outcome reporting; 6: free of other problems.
Similar(53)
Our study shows, not unexpectedly, that patients who have completed advanced school have a higher level of knowledge irrespective of allocation to education or control group.
To minimize bias that could have arisen from knowledge of treatment allocation, all outcome assessors were blind to treatment allocation and a random sample of outcome measures was re-rated by independent assessors.
MedSciNet generated the allocation sequence; trial staff had no prior knowledge of the allocation sequence.
All patients were blinded for group allocation and data analysis was carried out without knowledge of group allocation.
As rehabilitation studies are rarely masked to treatment allocation, it is problematic for parents to report perceived QOL without knowledge of treatment allocation, introducing bias.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com