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While the gain in biological knowledge is substantial, the supertree approach is not undisputed.
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And the contributions of today's undergraduates to the pool of knowledge are real and substantial: It's not uncommon to see scientific publications in excellent journals with undergraduate first authors.
Biochemical studies on intact polyketide synthase proteins have amassed a body of knowledge that is substantial but still incomplete.
As illustrated in Fig. 1, based on current available knowledge there is substantial complexity in the mechanisms by which 5-HT influences liver injury and repair, with multiple effects on different cell types and the activation of cell-cell signaling pathways that link epithelial cell regeneration and fibrosis.
For example in the area of medicines for diabetes one GP commented: " I think it doesn't affect someone if your knowledge of diabetes is substantial but if your diabetes knowledge is not that good it offers a lot of advice of what might be the best thing to do with –it does depend on the doctor's level of knowledge.
Knowledge is a substantial factor for auditors to provide expert performance (Bonner and Lewis 1990) and with the help of broader knowledge experts can perform more efficiently (Bédard and Chi 1993).
There is substantial knowledge of individual risks for bleaching, cyclones, disease and A. planci.
Although there is substantial knowledge of how climate change can affect human health, there is much the scientific community does not know or understand.
Finally, there is substantial public health knowledge to be gained from this research.
Although these reviews suggest that there is substantial evidence that knowledge improves following educational workshops, there is a lack of information about similar improvements in skills [ 32].
The cost of studying these 750 laboratory animals is substantial, yet the knowledge gained applies only to one temporal sequence of exposures at one postexposure time point (Suk et al. 2002).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com