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This leads many to conclude that genuine scientific knowledge has been demonstrated beyond all doubt.
The power of integrative analyses utilizing genomics data and functional knowledge has been demonstrated in the analysis of individual datasets [ 16] and systematic efforts to expand our understanding of gene functions [ 17- 20].
[ 27] The capability of providing sufficient information regarding to particular genetic diseases or genetic tests and recommending appropriate genetic tests based on the clinical observation and professional knowledge, has been demonstrated in our previous study.
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Gaps in patient and physician knowledge have been demonstrated in addition to their perception of treatment related issues in gout, including non-adherence [ 15].
Knowledge discovery has been demonstrated as an effective approach to extracting knowledge from existing data sources for soil classification and mapping.
The main reason for this has been the emphasis placed on promoting dental knowledge, which has been demonstrated to have little effect neither on oral health behavior nor on oral health [ 1].
Secondly the semiphysiological modeling approach may also be of relevance to generate informative PK study designs in pregnant patients based on available knowledge, as has been demonstrated previously [ 13].
Although it is generally assumed that both HDACs can be paired within the same complex, to the best of our knowledge, it has been demonstrated only in studies using exogenously expressed, tagged HDAC1 and not in studies characterizing endogenous HDAC corepressor complexes [ 36].
To our knowledge no phenotype has been demonstrated for a duplication of this gene, but clinical relevance cannot be excluded.
This migration-induced transmission of knowledge, norms and values has been demonstrated to affect the up-take of low-fertility norms (Beine et al. 2013) but also the political realm (Spilimbergo 2009).
However, to the best of our knowledge, no authentic GPCR has been demonstrated to bind to lipoproteins as signalling molecules and therefore it should be a crucial step forward to de-orphanize this family of GPCRs in Ciona.
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