Sentence examples for knowledge defects in from inspiring English sources

However, the vascular phenotype of Adam17ΔZn/ΔZn embryos' seems unlikely to be attributable to a loss of soluble TNF-α or TGF-α; to our knowledge, defects in embryonic vascularization or a bleeding phenotype have not been reported in mice expressing a non-cleavable form of TNF-α [18], [19] nor in animals deficient in TNF-α [20] or TGF-α [21].

However, to the best of our knowledge, defects in chromosome condensation have not been described in fission yeast, possibly because the level of DNA condensation could not be assessed easily by DAPI staining of the small chromosomes.

To our knowledge, the defect in autophagy in DU145 cells upon various stimuli has not been reported previously.

These studies may, however, be biased by prior knowledge of reported defects in mitochondrial function.

Familiarity with the basic components of the UPS and knowledge of UPS defects in neurological diseases will definitely be of future importance in neuropathology.

Indeed, emerging knowledge of gene defects in males (Klonisch et al. 2004) suggests a common cause for cryptorchidism and sensitization to a tumor-inducing agent.

Together, these findings highlight the importance for a detailed knowledge of genetic defects in tumors to identify those patients who will most likely respond to specific genotoxic drugs.

In this section, we summarize the knowledge on protein homeostasis defects in PH1 to provide a comprehensive and integrated perspective of PH1 as a folding disease.

The second approach - the design of therapeutic strategies from knowledge about particular gene defects in individual tumours - is illustrated by the development of poly ADP ribose polymerase (PARP) inhibitors for breast and ovarian cancers in patients harbouring BRCA1 or BRCA2 mutations.

There are two remedies for the defects in our knowledge of "what" God is, one taken from faith, the other from reason.

In spite of steady improvements in performance, important defects in fundamental knowledge remain about wetting properties, oxygen reduction kinetics, corrosion paths and control mechanisms.