In this study, in silico approaches, that is, the knowledge based motif discovery and de novo motif discovery were used to identify the regulatory motifs of 79 Mtb TA systems.
The knowledge based motif discovery approach was used to design a Perl based bio-tool Mtb-sig-miner available at (https://github.com/zoozeal/Mtb-sig-miner), which could successfully detect sigma factor specific regulatory motifs in the promoter region of Mtb TA modules.
The teacher made learners externalize their discovery by inquiries and explained knowledge based on their externalized discovery.
"The current AI movement is based not on new fundamental discoveries but mostly on the abundance of knowledge based in the sphere of algorithms and technologies in various areas if AI and of course increase in computer capacity contributes a lot to AI development.
The promise of artificial intelligence and other branches of computer science is to radically transform conventional discovery environments by equipping scientists with a range of powerful computer tools including large-scale, shared knowledge bases and discovery programs.
The KB-builder framework aims to speed up the immunological research and vaccine design by providing specialist knowledge bases that host cleaned, well-annotated and structured data suitable for the discovery of new knowledge.
This analysis shows that bioactivity profile comparison can provide insights into the mode of actions at the molecular level, thus will facilitate the knowledge-based discovery of novel compounds with desired pharmacological properties.
Findings validate traditional usage of medicinal plants through scientific explanation of their efficacy for the prevention and treatment of diabetic symptoms and provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic.
Although we show how our analysis could be extended to accommodate these three alternative interpretations in each case, such an extension would hide other problems in the BioModels knowledge base from automated discovery.
In this paper, a genetic algorithm (GA) based knowledge discovery system is proposed to discover knowledge about the fluid dispensing process.
As one of the extension researches of KDTICM [Bingru, Yang (2004). Knowledge discovery based on theory of inner cognition mechanism and application.
