X-ray crystal structures of acetylcholine binding proteins (AChBPs) have revealed two different possible extensions to the classical ligand binding pocket known to accommodate various nicotinic agonists.
The Eastern Betic Shear Zone (EBSZ) in Southern Iberia is known to accommodate part of the 4 5 mm/yr convergence between Africa and Iberia, but its seismic hazard is not sufficiently understood for an accurate risk assessment.
Earth, also called the world and, less frequently, Gaia, (or Terra in some works of science fiction ) is the third planet from the Sun, the densest planet in the Solar System, the largest of the Solar System's four terrestrial planets, and the only astronomical object known to accommodate life.
Furthermore, uniquely in the FABP family, LFABP is known to accommodate two fatty acids as well as other bulky and rigid ligands such as fatty acid-CoA thioesters, lysophosphatidic acid, bile salts, heme, 1,8-ANS, lipophilic drugs etc. [1], [3], [4].
For example, the Pit-1 homodimer is known to accommodate flexible spacing between its half-sites [ 4].
Moreover, the left IFG is well known to accommodate Broca's speech area (Lindenberg et al., 2007) and its activation might therefore also reflect covert speech.
The 3/3 globin fold is known to accommodate several such molecules, for example chlorophyllin, chlorophyllide, and open tetrapyrroles, and the same might be expected of the 2/2 proteins.
Other transcription factors are known to accommodate variable length binding sites for their DNA interactions, for example, p53 [ 5] and the Stat family of proteins [ 6, 7].
FXR is known to accommodate a flexible ligand binding domain, where ligand binding changes the position of the AF-12 helix and thus the recruitment of co-activator or -repressor proteins.
This domain of p53 is known to accommodate several post-translational modifications, which, at least theoretically, can modulate its ability to bind (and hence regulate the activity of) SERCA.
