Using properly collimated γ-ray sources, it is possible to select events with known interaction location.
Along with multiple known interaction partners we identified novel candidates including proteins that had already been linked to ciliary function.
In general, participants preferred methods that resemble already known interaction paradigms, and argued against the need of moving physically.
BIAcore is generally used for kinetic characterization of a known interaction between two biomolecules.
The baz zygotic mutant cuticle phenotype could be dominantly enhanced by loss of known interaction partners.
As a proxy for divergence in interaction domain, one can consider the overlap in known interaction partners.
Fig. 1 summarizes the interaction motifs and domains of the protein as well as its known interaction partners.
This is consistent given the known interaction of TDP-43 and FUS.
Only proteins with at least one known interaction in HPRD were taken into account.
As an example, Additional file 5 shows known interaction partners of CDX2.
