Suggestions(5)
Exact(2)
"The It's A Knockout type of thing is really good," Harman says.
The studies showed that infection of (knockdown or knockout) Type I interferon (IFN) receptor-deficient mice with ZIKV resulted in chronic inflammation of the testes and epididymides (Govero, Esakky et al. 2016) (Ma, Li et al. 2016).
Similar(57)
You stretch out, and beautiful, knockout-type girls come and scrub you head to toe".
In addition, the molecular mutation spectrum was found to be changed in favor of generating knockout-type alleles by ~20%, resulting in an overall increase in efficiency of ~2.5 fold.
The chance of generating a knockout-type allele was found to be increased by ~21% in the MMR-deficient background (from 4.26% for wild type to 5.16% for the msh6-/ mutation spectrum).
Indeed, deficiency of Msh6 was found to improve the ENU-driven knockout procedure in two ways; 1) it increases the ENU-induced germ line mutation frequency up to 1 mutation every 585 kb and 2) the mutation spectrum is changed and enhances the chance of generating a knockout-type allele by 21%.
The chance of generating a knockout-type allele was calculated for all 768 working amplicons by comparing the probability of nonsense mutations and splicing donor/acceptor mutations divided by all changes in coding sequence plus splicing donor/acceptor sites (first two and last two nucleotides of each intron), all corrected for the wild type and mutant mutation spectra.
Based on the mutation spectra obtained in wild type and Msh6-deficient backgrounds we calculated the chance of generating a knockout-type allele by introducing a premature stopcodon or mutating splicing donor/acceptor site for the 768 amplicons that were used in our screen.
In a different context, the knockout of type IX collagen altered the time course of callus differentiation during bone fracture healing, and delayed the maturation of cartilage matrix (Opolka et al., 2007).
* indicates p < 0.05 between both knockout:wild-type and knockout:heterozygous animals.
Raw data for the knockout, wild-type, and heterozygote mice can be accessed in File S5.
More suggestions(2)
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com