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There is a lack of clarity on the phenotype and stages analyzed for the Scx-Cre-Mmp14 tissue specific knockout compared with the null.
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Additionally, the signal for CTGF was increased in ITGA2 knockouts compared with wild-type mice.
In contrast, there was no statistical difference in cleaved caspase-3 in VSMCs from MMP-3, -9, and -12 knockouts compared with controls.
By contrast, VE-cad in other tissues, such as the developing lung (Fig. 10C-F), showed a significant reduction in the knockouts compared with wild-type controls.
The tubulointerstitial fibrosis score (range 0 to 2) was 1.1 at 150 days in ITGA2 knockouts compared with 0.3 in wild-type mice.
Further studies by this group subsequently demonstrated the importance of HIF in the regulation of phagocytic bactericidal capacity in vivo [ 39], with decreased bactericidal activity and exaggerated systemic spread of infection in conditional HIF-1α knockouts compared with littermate controls.
To do this we quantified the yields of siliques in clipped and unclipped plants harboring single invertase gene knockouts compared with the parent Col-4 line and the undercompensating L er.
In another study a β-cell knockout was compared with whole body knockout mice that had been fed a high fat diet.
In brachiocephalic atherosclerotic lesions the cross-sectional area of the plaque was increased by 54% in ApoE/COMP double knockout mice compared with ApoE single knockout controls (p = 0.039, Mann Whitney test) (Table 1, Fig. 2).
We report that the rate of repair of oxidative and alkylation-induced single-strand breaks is reduced in Tdp1−/−/ Aptx−/− double knockout astrocytes, compared with Tdp1−/− or Aptx−/− single knockouts.
Chelsea put this down to their elimination from the Champions League in the first knockout round compared with a semi-final appearance in 2014.
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