Exact(7)
A detailed description of the generation of Thap1 knockout, i.e. null, mouse is provided in Ruiz et al. (unpublished data).
A low overlap between knockout and binding targets for a given TF reflects the high insensitivity of TF binding targets to the TF knockout (i.e. robust transcriptional regulatory program).
Moreover, we grouped the transcripts according to whether their mRNA/pre-mRNA ratios were significantly increased in the Dicer knockout (i.e., transcripts more likely to represent direct miRNA targets; N = 167) or not (i.e., transcripts less likely to represent direct miRNA targets; N = 505).
In my mind, when I didn't get the knockout, I said forget about it".
It's gonna be a knockout, I'm sure".
Colin Hart: After the knockout, I did something that I was a bit ashamed of, because it was unprofessional.
Similar(53)
(if 3 points for every win; group stage & knockout) Is your team here?
For all our networks, double knockout analysis required solving 5 to 20 times as many LPs than single knockouts, i.e., classical FCA.
Single KOs impact: Average impact of single reaction knockouts, i.e., average number of reactions classes that become blocked by a single knockout.
Comparison of the fraction of correctly predicted lethal knockouts (i.e., specificities) of microbial genome-scale metabolic models against the yeast iMM904 model for single gene mutation experiments.
As noted above, we selected the most parsimonious solution and focused on specific knockouts, i.e. those having a small p-value.
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