The association of KIT with high growth fraction is consistent with presumed proliferation promoting effect of KIT.
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The CD45− enriched melanoma cells displayed differential binding to CD117 (c-KIT), with higher levels associated with decreased DMFS on univariate analysis with borderline significance (HR = 1.56; p = 0.07).
Further immunohistochemical analysis suggested that TNBC in Malaysian women was strongly associated with EGFR, CK5/6 and c-KIT expression with high a Ki-67 proliferation index.
The sum of the ABL1 copy numbers observed at 0.32%, 0.032% and 0.0032% was calculated and a score of 1 to 6 was assigned to the individual kits, with the highest score being assigned to the kit with the highest copy number, in this case SuperScript® III Reverse Transcriptase (Additional file 1: Table S2).
To overcome this, we prepared modified kits that can produce a [99mTc(CO)3]+ solution with radiochemical purity equal to that of the unmodified kits but with higher radioactivity concentration.
With 16 analyzed loci, the Powerplex16 (Promega, Madison, USA) and the AmpFlSTR® Identifiler (Applied Biosystems, Foster City, USA) are currently the commercially available forensic DNA profiling kits with the highest number of analyzed loci.
Despite improvement in median coverage across the exome with newer capture kits and with higher sequencing depths, the coverage of individual genes was non-uniform.
A majority of commercially available exome capture kits target with high-confidence a subset of genes annotated by the Consensus Coding Sequence (CCDS) project [ 25] and the RefSeq collection [ 26].
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