Sentence examples for kinetic knowledge from inspiring English sources

The approach does not require any (approximate) kinetic knowledge, and is thus considerably easier in implementation than the extended Kalman filter approaches.

Power-law formalism or S-system theory was developed by Savageau et. al [27], [28] and it is a useful methodology to describe complex biological interactions, in particular when detailed kinetic knowledge of the underlying biological processes is unknown [27], [28].

Due to the high number of free parameters however, these models are often used under presumptions such as the availability of large amounts of data [ 10], a known network structure, constrains regarding the network structure [ 11, 12], or additional kinetic knowledge [ 13] or assumptions (such as nonlinear sigmoidal activation functions as used by Mjolsness et al.[ 14] or Toepfer et al.[ 8]).

Again, the flux through these "mini-cycles" needs to be equivalent to the protein synthesis flux (figure 7A), and for several nucleotide exchange reactions there is sufficient kinetic knowledge available to predict the maximum sustainable flux if intracellular factor concentrations are known.

An increase of eIF2B levels to 1.6 μM would be required to achieve guanidine exchange rates at the upper limit of the 90% confidence interval for translation rate estimates produced here, and it can be concluded that the available kinetic knowledge on eIF2 nucleotide exchange matches translation rates predicted from the genome-wide datasets very closely.

Therefore, with partial kinetic parameter knowledge, dynamic models can be used to generate constraints that reduce the solution space below that identified by constraint-based models, eliminating infeasible solutions and increasing the accuracy of simulation and optimization methods.

This chapter is thus aimed at introducing the basic concepts of electrochemistry related to corrosion to show to the reader how the different variables have to be handled to build up the thermodynamic and kinetic basic knowledge crucial for anyone involved in corrosion inspection, design, and maintenance or in corrosion-related research.

These methods allow the simulation of genome-scale networks, do not require kinetic enzymatic knowledge and are suited to test the outcome of gene deletions [ 6- 8].