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They analysed 59 patients with medulloblastoma - the most common kind of malignant brain tumour in children - aged between three and 21 from 2003 to 2009.
Fourteen percent knew about relatives with some kind of malignant liver disease (table 1).
In addition, it is unknown whether the BM milieu per se presents some kind of malignant transformation.
We identified 10 patients suffering from some kind of malignant tumor and a further 26 patients with chronic organ diseases.
The exclusion criteria were the following: metastatic disease at presentation, prior history of any kind of malignant tumor, bilateral breast cancer at presentation, any type of neoadjuvant therapy, development of loco-regional recurrence during the follow-up period, development of a second primary cancer, and absence of sufficient tissue in paraffin blocks.
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During the multistep process, cancer cells acquired several hallmark capabilities which enable them to become tumorigenic and show all kinds of malignant phenotypes (Hanahan and Weinberg, 2000, 2011).
The expression of CENP-H in various kinds of malignant tumors has been reported [ 14].
It has been shown to trigger cytotoxicity in inflammatory diseases and against development of many kinds of malignant tumors.
We also have to verify if this is also effective for patients using regimens for other kinds of malignant tumors.
Interestingly, survivin is widely expressed in all kinds of malignant tumors, making it a potent target for cancer therapy.
The modification of HE4 by Lewis y antigen enhanced tumor cell invasion, proliferation, adhesion, and other kinds of malignant behavior [ 10, 11, 16].
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