Our study demonstrates that parenchymal, tissue-forming cells can also express Perforin-2 and its expression in these cells is essential for killing of bacteria.
Van Acker, H. & Coenye, T. The role of reactive oxygen species in antibiotic-mediated killing of bacteria.
However, a wide variety of pathogens subvert complement attack by binding host complement inhibitors, which results in diminished opsonophagocytosis and killing of bacteria by lysis.
Selective killing of bacteria in a mixed population is enabled by engineering an antimicrobial that is toxic only in pathogens harboring specific genetic elements.
Conversely, deletion of a gene that helps coupling oxygen consumption with energy production artificially ramped up respiration rates and at the same time boosted killing of bacteria treated with bactericidal antibiotics.
However, a wide variety of bacterial pathogens subvert complement attack by binding host complement inhibitors such as C4b-binding protein, factor H and vitronectin, which results in diminished opsonophagocytosis and killing of bacteria by lysis.
More importantly, due to their intrinsic absorption of NIR light, glutaraldehyde-modified PEG-W18O49 are successfully applied as fault-free targeted photothermal agents for imaging-guided killing of bacteria on a mouse infection model.
Mechanistic investigations through combined studies of SEM and fluorescence assays revealed that the killing of bacteria and cancerous cells was caused by disrupting cell membranes, initiated by electrostatic interactions between cationic peptides and negatively charged cell membranes.
Use of gold in the killing of bacteria has been focused to some treatments of arthritis [18, 19].
The relatively slow killing of bacteria and fungi by millimolar NCT appears to approximately correlate with its penetration into the cytosol of these organisms.
This results in the killing of bacteria in two ways.
