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When drug concentrations which had achieved identical killing capacities on MUC16-negative Jurkat cells were compared, we consistently found ≈ 6 to 8-fold stronger signal intensities for Meso-TR3 compared to TR3 (Additional file 1: Figure S1).
Second, worse polymorphonuclear killing capacities against pathogens, as assessed by concentrations of lysosomal enzyme or burst respiratory intensity, are observed when BGL is poorly controlled with a dose-effect relationship in diabetes [ 38].
Circulating numbers of NK cells increase with age and total NK cell pool activity appears to be maintained with aging; however, the per se killing capacities and IFN-γ producing capacities of these cells appears to be impaired, perhaps due to an age-associated shift towards a "mature phenotype" (Solana et al 1999; Mocchegiani and Malavolta 2004; Plackett et al 2004).
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Under the assumption that the mesothelin epitope of Meso-TR3 would not impact the killing capacity of the MUC16-targeted TRAIL fusion protein, we established the killing curves for TR3, Meso-TR3 and recombinant TRAIL (rTRAIL) and identified conditions under which all TRAIL drugs induced cell death to the same degree in the absence of the tumor marker MUC16.
In addition, affinity maturation of the antibody fragment on Fab phages allows improvement of the tumor cell killing capacity of chimeric Fab receptor engrafted T cells.
By ending his story when America stopped whaling, Dolin omits the most gruesome years of international whaling history, when new technology increased killing capacity approximately tenfold.
Halle, S. et al. In vivo killing capacity of cytotoxic T cells is limited and involves dynamic interactions and T cell cooperativity.
Effective immunomodulation to induce tolerance to tissue/organ allografts is attained by infusion of donor lymphocytes endowed with killing capacity through ectopic expression of a short-lived Fas-ligand (FasL) protein.
Even with a fleet of constant size, the so-called "technological creep" increases the average fleet's killing capacity by about 4% a year.Lots of today's trawlers in places like the North Sea are big and fuel-thirsty.
Various strategies have been applied to improve the cancer cell killing capacity of CRAD.
The macrophage killing capacity was quantified by a gentamicin protection assay following a modified protocol described for Salmonella [21].
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