It has been shown that IL-15 in mammals has a major role in natural killer cell development and proliferation, T cell growth, B cell proliferation and differentiation, and has an important influence on the development of CD4+ T cells [ 10, 11].
Yu, J., Freud, A.G. & Caligiuri, M.A. Location and cellular stages of natural killer cell development.
Freud, A. G. et al. NKp80 defines a critical step during human natural killer cell development.
Yu, J., Freud, A. G. & Caligiuri, M. A. Location and cellular stages of natural killer cell development.
Gascoyne, D.M. et al. The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.
In this review we compile several studies on using genetic modified mice and humanized mice to study function of transcriptional factors in lymphopoiesis, including T lymphocyte and Natural killer (NK) cell development.
Orchestration of invariant natural killer T cell development by E and Id proteins.
Thus, in addition to maintaining genome integrity during Tcra rearrangements, PAXIP1 controls distinct transcriptional programs during DP differentiation necessary for Tcra locus accessibility, licensing mature thymocytes for trafficking and natural killer T cell development.
Moreover, PAXIP1 was essential for release of mature single positive (SP) αβ T cells from the thymus through transcriptional activation of sphingosine-1-phosphate receptor S1pr1 as well as for natural killer T cell development.
Interleukin 4 (IL-4) suppresses the interleukin 2 (IL-2) induced lymphokine-activated killer (LAK) cell development from human peripheral blood mononuclear cells (PBMC).
Defects in γc signaling components result in impaired B, T, and natural killer (NK) cell development, leading to severe combined immunodeficiency in humans and mice [ 30, 31].
