Opioids are commonly used in the management of post-operative pain, and often a standard dose is used by the health-care providers without taking into consideration kidney function.
However, the study purpose was to examine the usefulness of simple clinical parameters to help clinical decision-making (e.g., urea level does not need to take into consideration kidney function in CURB-65).
On the basis of the available studies, using IBW in colistin dosing is recommended, taking into consideration the kidney function.
However, recent limited data suggested the consideration of kidney function before initiation of argatroban therapy in HIT [ 13, 17, 18].
In contrast, recent limited data suggested consideration of kidney function and dose adjustment in HIT therapy with argatroban [ 13, 16- 18].
Consideration of kidney function is important for evaluating REE because the oxygen consumption of the kidneys is high – estimated to be between 5.6% and 20% of the total metabolic rate [ 28, 29] – and failing kidneys may have reduced oxygen consumption contributing to reduced REE [ 29, 30].
Antibiotic dosing in obese patients should take into consideration these variations in kidney function.
Patients with CKD have a high burden of co-morbidities that modulate pain response, and when these individuals undergo operative procedures, standard orders for pain control can be written without taking into consideration the patient's kidney function.
It is common for these patients to be cared for by 'non-nephrologists' who often prescribe the standard dose of the commonly used analgesics, without taking into consideration the patient's kidney function.
Kidney function is often compromised in frailty and is a key consideration in medication choice and dosing; however, creatinine-based measures of kidney function may be biased in frail individuals.
Confounding the decrease in drug elimination rates due to reduced hepatic and kidney function, the older HIV patient population has more comorbidities that require consideration when choosing a cART regimen.
