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Detection of the N-acetyl cysteine conjugate of the unsaturated parent telomer alcohol in urine from female rats and not male rats provides some evidence to support the mechanistic basis for the observed kidney effects.
As magnesium crosses the placental barrier and since the fetal kidney does not excrete magnesium as efficiently as the mature kidney, effects on fetal cardiac time intervals are probable, but still unknown.
Long-term exposure to methylene chloride can cause headaches, depression, nausea, mental confusion, liver effects, kidney effects, visual disturbances, and cancer in humans.
See Table 1 for further information on kidney effects.
Several of the studies of bone effects also assessed kidney effects in parallel.
This suggests that Cd may produce a primary bone effect independent from its kidney effects.
Thus far, the critical UCd levels for kidney effects have displayed large variations.
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The kidney effect was "a modest benefit," said Dr. David Nathan, director of the diabetes center at Massachusetts General Hospital.
The cadmium-associated kidney effect markers were further evaluated in multiple linear regression models, where each kidney effect marker was evaluated in relation to cadmium and confounders/covariates.
The study population characteristics, exposure variables, and kidney effect markers are presented in Table 1.
Smoking (pack-years) was not associated with any of the kidney effect markers.
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