Sentence examples for kidney conditional from inspiring English sources

Kidney conditional Yap-knockout transgenic mice were also not available in the present study.

For instance, in the kidney, conditional knockout of genes essential for ciliogenesis in adult animals does not result in immediate or uniform kidney cyst formation, raising questions of how cilia detect fluid movement in vivo and how they function in normal epithelial homeostasis [ 3].

To study the role of DG in the kidney, different conditional knock-out mice were created to selectively delete DG from podocytes, ureteric bud, metanephric mesenchyme derivatives, and all renal epithelial cells using the Cre-lox system under the control of podocin, HoxB7, Pax-3, and Pax-2 promoters, respectively [ 64].

Renal tumors were resected from BHD patients and kidneys were collected from Flcn-heterozygous or kidney-specific conditional Flcn knockout mice [24], [26].

Data from a total of 8 independent arrays were used in this study, 2 arrays were used for RNA samples from E18.5 control kidneys, 2 for E18.5 Lim1 conditional mutant kidneys, 2 for E14.5 control kidneys, and the other 2 for E14.5 Lim1 conditional mutant kidneys.

To study agrin in adult kidney, a new conditional allele was used to generate podocyte-specific knockouts.

Comparison of the E14.5 control kidney and Lim1 conditional mutant kidney gene expression profile picked up only 41 genes that showed a more than 2 fold change (Table 1).

We analyzed the role of miRNAs in kidney development by conditional gene deletion of Dgcr8 in the developing kidney using a transgenic mouse line that expresses Cre recombinase in the distal nephron and derivatives of the ureteric bud in kidney development.

To generate an E18.5 nephron-specific gene list, we compared gene expression data of E18.5 control kidney (E18.5C) and Lim1 conditional mutant kidney (E18.5M).

A total of 465 genes showed a more than 2 fold increase in expression in the control kidney compared to the conditional mutant kidney (Table 1 and Additional file 4).

To bypass the early lethality that hinders the analysis of Lim1 function in kidney organogenesis, a Lim1 conditional null allele in mouse was generated [ 22].