Sentence examples for ki up from inspiring English sources

Replacement of aromatic amino acids in the acyl pocket with aliphatic residues increases ki up to 130-fold, with substitutions at Phe295 (Phaving having the greater effect.

Several compounds displayed micromolar affinity (Ki up to 23 μM), favorable selectivity (up to > 26-fold), and low cytotoxicity.

Among them, compounds 7i, w, y with Cl, CN or NO2 groups at the 4-position of the benzamide scaffold showed excellent affinity for S1R (Ki = 1.2 3.6 nM), selectivity for S2R (Ki up to 1400 nM) and high selectivity index (IC50 SY5Y /Ki (S1ratiotio from 28 000 to 83 000).

Title compounds were designed as dual drugs for tackling simultaneously the Gaucher disease (by selective inhibition of β-glucosidase, Ki = 1.6 5.5 μM, with improved potency and selectivity compared to deoxynojirimycin) and its neurological complications (by inhibiting AChE, Ki up to 5.8 μM).

Despite this, the concentration of endocannabinoids required in the present study are in line with the known receptor affinity for AEA at CB2 receptors (Ki up to 2 μM) and TRPV1 channels (EC50 ranging from 0.63 to 4.9 μM depending on assay) (Pertwee et al., 2010) and for OEA and PEA at PPARα (EC50 3–4 μM, O'Sullivan, 2007).

Ki links up with international colleague Ji Dong-won at the Stadium of Light.

Ki grew up in a wealthy Hong Kong family that served steaming bowls of shark fin soup to honor guests at birthdays, banquets and weddings.

Summing up ki ho'alu once, he said: "It's sweet, it's good for the soul".

You might get away with it but there are some subtleties in postnatal care that I think only midwives would be able to pick up (KI, Obstetrician, Metropolitan, 2016-3).

It was amid such chaos that the Koreans bustled through a packed defence with Ki teeing up Son who finished coolly past Ryan a minute into injury time.

However, xylose tolerant β-xylosidases have been reported to exist with Ki values up to 200 mM (Yan et al. [2008]; Zanoelo et al. [2004]).