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The present study describes the scaling up of the fluidized granulation process from small (5 kg scale) to medium (30 kg scale) and to production fluid bed scale (120 kg scale).
For such a goal, it is mandatory to reach very low threshold in energy (at or below the keV level), very low radioactive background (at a few counts/keV/kg/day), and high detection mass (at or above the 100 kg scale).
However a full test of the WIMP hypothesis will require a scale up from current experiments at the kg scale to experiments at the ton scale or beyond.
We developed a high-yielding synthesis of atorvastatin calcium salt on 7 kg scale that affords >99.5% product purities by introducing the following key improvements: i. isolating the pure product of the ketal deprotection step as crystalline solid, and ii.
The yield was still sufficient for biological and chemical characterization from a single 1 kg scale experiment.
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Finally, larger-scale experiments were carried out with batches of 1 and 50 kg (scale-factors of 100 and 5000, respectively) and the results were consistent with those obtained at laboratory scale.
Thus we have carried out iodide-enhanced EKR experiments at the lab (16 g of soil) and semi-pilot (2 kg) scales.
Body weight was measured to the nearest 0.1 kg (Scale-tronix 6702 W; Scale-tronix, Carol Stream, IL) in minimal street clothing without shoes.
The masses of our three volumetric reconstructions of Dreadnoughtus (figure 1 a– c and table 1) are equivalent to 37, 47 and 64% of the 59 300 kg scaling equation mass.
This systematic approach, developed on the basis of mechanistic understanding of the critical material and process attributes for ordered mixing and segregation, allowed us to consistently manufacture tablets with high content uniformity both at 1-kg scale and 40-kg scale.
The SuperCDMS SNOLAB experiment will be a 20-kg scale Si and Ge direct dark matter detection experiment designed to probe down to 300 MeV in dark matter (DM) mass through DM-nucleus scattering and 500 keV in DM electron scattering.
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