These data strongly support our supposition that ephrin-B1 induction is a key wound-activated signal for triggering loosening of basal epidermal junctions to enable forward migration of cells to facilitate repair of the wound gap.
We have previously shown that DDR2 phosphorylation drives key wounding responses in skin fibroblasts including proliferation, chemotactic migration and secretion of both metalloproteinases and fibrillar collagen.
Because of the price -- the average alarm clock is under $15 -- the traditional key-wound device, like the recognizable Big Ben (which double-handedly popularized the idea of personal wake-up alarms by the 1940's), still rules the market.
A report revealed that a honey dressing enhances wound contraction in fresh wounds, which is one of the key features of wound healing [ 27].
Hypoxia plays an important role in regulating gene expression in both the lens and in solid tumor tissues as well as a key role in wound healing, ischemia/reperfusion injury, and prenatal development.
Oxygen plays a key role in wound healing, and hypoxia is a major cause of wound healing impairment; therefore, treatments to improve hemodynamics and increase wound oxygenation are of particular interest for the treatment of chronic wounds.
As mentioned above, TGF-β1 is a key regulator of wound epithelium formation, inflammation, blood clot formation, and ECM remodeling in mammalian wound healing processes [5], [26], [27], [32], [33].
TGF-β1 plays a key role in wound healing and in vivo, TGF-β1 expression is decreased in wounds of elderly females compared with younger counterparts, a reduction reversed by estrogen replacement, suggesting that estrogen may indirectly influence granulation tissue formation by altering cytokine profiles within healing wounds.
We suggest this multiscale model offers a valuable, easy-to-visualize aid to our understanding of the actions of this key regulator in wound healing, and provides a model that can now be used to explore pathologies of wound healing.
