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We focused our analyses of exposure response relationships on key transition metals that can generate reactive oxygen species by Fenton-type reactions: vanadium (V), chromium (Cr), iron (Fe), nickel (Ni), copper (Cu), manganese (Mn), lead (Pb), and zinc (Zn).
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Beyond that, transition metals are key factors in the pathogenesis of stroke, Alzheimer's and Parkinson's diseases, among others [ 1, 6– 13].
When we measured the soluble (water-desorbable) metal released by each NP type, we found a relationship between the ranking for the amount of soluble metal released by any NP type and the activity in the assays, with the key exception of alumina 2. Transition metals were most common in the NPs generating large amounts of free radicals, but the overall levels were low.
Catalysis of chemical reactions by nanosized clusters of transition metals holds the key to the provision of sustainable energy and materials.
Chemotherapies based on transition metals play a key role in cancer treatment, and among them platinum and palladium are the most fruitful.
Understanding the interaction of α,β-unsaturated carbonyl compounds with late transition metals is a key prerequisite for rational design of new catalysts with desired selectivity towards C = C or C = O bond hydrogenation.
The recently published data [ 27], including our analysis of Zn and Cu handling [ 20, 28] strongly indicates a key role of lysosomal exocytosis in clearance of transition metals.
While this Review focuses on transition metals, we discuss some of the key advances/milestones achieved in the development of fluorescent Ca2+ indicators as these helped lay the groundwork for much of the subsequent work developing sensors for transition metals.
Therefore, the synergistic effect derived from multiple transition metals and unique nanostructure may be the key for excellent electrocatalytic properties.
Transition metals (e.g. NiII, CuII) are key constituents within the considered systems, playing a distinctive architectural role and favouring electron transfer processes.
Transition metals such as iron and zinc are key factors in numerous biological processes as both, structural and catalytic cofactors for proteins.
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