Sentence examples for key stimulatory from inspiring English sources
An unusual feature of the hair follicle stem cell niche is that one of its key stimulatory components is transient.
The wound-induced increase in ethylene, seen within 3 h of production of the cuttings, is a key stimulatory factor in the formation of root primordial [ 36].
Promitogenic effects of mid-range concentrations of PGE2 were mimicked by the EP3-selective agent (sulprostone) identifying EP3 as the key proliferative stimulatory receptor.
While these cells efficiently internalized LNP, mainly monocytes and DCs translated the mRNA and upregulated key co-stimulatory receptors (CD80 and CD86).
The key co-stimulatory and co-inhibitory receptor-ligand pairs belong to the B7 and tumor necrosis factor (TNF) families [228, 229] although accessory molecules belonging to different families might also be important.
Recent advances in studies of T cell memory have implicated the tumor-necrosis-factor receptor (TNFR) family member, OX40 (CD134), as a key co-stimulatory molecule involved in the regulation of CD4 memory T cells.
CD28 is a key co-stimulatory molecule that is essential for T cell activation and survival [ 17].
PRRs when stimulated by PAMPs lead to activation of adaptive antigen-recognition receptors subsequently inducing the expression of key co-stimulatory molecules and cytokines [ 2] as well as maturation and migration of other cells.
ICOS is a key co-stimulatory receptor and, alongside its role in promoting CD4+ Teff-cell responses, it is becoming clearer that ICOS can influence Foxp3+ Treg-cell development and function in autoimmune settings 18, 19, 21.
One of the key co-stimulatory mechanisms involves the interaction of CD28 on the surface of the T cell with B7 molecules CD80 or CD86 on antigen-presenting cells.
We hypothesized that by term protein expression of several key IGF system stimulatory peptide pathway components and downstream nutrient signaling effectors of IGF, mammalian target of rapamycin (mTOR) and S6, would decrease, indicating reduced cellular nutrient uptake and protein synthesis.
