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The frequency of uncultured Prevotella clone PUS9.180 suggests the possible key role of this Prevotella species in acute endodontic infections.
This finding is entirely consistent with our data from proliferating myoblasts, strongly suggesting a key role of this modification in the pathogenesis of MERRF.
Such a result was always improved with respect to those of the single folds, with the exception of the parallel structure (r2 equal to 0.886), thus suggesting a key role of this G4 conformation in the stacking interaction network.
The present findings, first time in the literature, demonstrated the startle and PPI elicited neuronal activity changes of the mPFC, and thus, provided evidence for a key role of this limbic forebrain area in sensorimotor gating process.
Comparison of ArMV and GFLV CPs reveals structural differences in the B domain pocket, thus strengthening the hypothesis of a key role of this region in the viral transmission specificity and identifies new potential functional domains of Nepovirus capsid.
Chmp7 expression was also found to be decreased in MN-1 AR65Q cells (Fig. 2C), and crucially, in laser capture microdissection (LCM) derived motor neurons isolated from spinal cord of presymptomatic AR100 mice (Fig. 2D), emphasising a key role of this gene in the early dysfunction of motor neurons.
The substitution of a proline at site 30 by an asparagine, an evolutionarily conserved functional residue in the scorpion α-KTx family, led to an increased activity on rKv1.2 and rKv1.3 but a decreased activity on the Shaker channel without changing the potency on rKv1.1, suggesting a key role of this site in species selectivity of scorpion toxins.
A large number of alkane MO sequences retrieved in this study showed the highest similarity with reference sequences belonging to Rhodococcus genus, suggesting a key role of this genus in TeCA/propane co-metabolism, while the remaining alkane MO sequences were mainly attributed to other Actinobacteria, to Bradhyrizobiaceae, and Cupriavidus genus.
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Recently, key roles of this family of TFs in epithelial cells and solid tumors also started to emerge (Taniuchi et al., 2012; Chuang et al., 2013; Scheitz and Tumbar, 2013).
To our knowledge, this is the first characterization of the functional role of PCA3 in PCa cells, and will not only improve the understanding of key roles of this transcript in prostate carcinogenesis, but also suggests an alternative strategy to use PCA3 as a putative specific target for PCa treatment approaches.
Cliff, with his gentle, soft voice, now took on the key role of providing this contrast in tempo and volume.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com