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Peroxisome proliferator-activated receptor γ (PPARγ) plays a key role in normal lung development.
Alternatively, a hormone may have a key role in normal body function (e.g., reproduction) and stress may deleteriously alter the hormone signal prevent normal function.
Apoptosis, or programmed cell death, plays a key role in normal tissue homeostasis ensuring a proper balance between cell production and cell loss.
Methyltransferase (MTase) is particularly important for viral replication, which also plays a key role in normal physiology and human infection through methylating DNA.
Serving a key role in normal immunological physiology, immune-sensing mediates the body's normal processing of senile cells, repair of damaged tissues, and immune destruction of malignancies (Huetz et al. 1988; Poletaev and Osipenko 2003).
More recently, it has been shown to play a key role in normal neuronal function [13], [14].
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Prof Scott Nelson, chairman of the RCOG Scientific Advisory Committee, said chemicals had the potential to interfere with hormone systems in the body, which play key roles in normal foetal development.
Angiogenesis plays key roles in normal development, wound healing, recovery from ischemic disease, and organ regeneration.
There is widespread recognition that reactive oxygen species (ROS) play key roles in normal brain function and pathology in the context of neurological disease.
DNA-binding proteins such as transcription factors play key roles in normal biological processes and in development of disease.
In summary, the Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt/mTOR cascades are complex, interacting pathways playing key roles in normal and malignant cell growth.
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