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Offices of world-famous companies sit across from knife sharpening and key repair booths.
One of the key repair objectives has been to restrengthen the building's reinforced concrete shear walls, which safeguard the entire structure by preventing destructive sideways shaking during a quake.
Brain plasticity and remapping is a key repair process after stroke and we study this at the circuit level using optogenetics, and at the synaptic level using electrophysiology and array tomography.
Non-homologous end joining (NHEJ), which does not depend upon sequence homology, is the key repair pathway during the G0/G1 stages of the cell cycle [10].
In similar manner, mice deficient in a key repair and transcription protein that unwinds DNA helices have premature onset of aging-related diseases and consequent shortening of lifespan.
A second exceptional case is RecA, the key repair protein that is required for homologous DNA recombinational repair following irradiation [20].
Similar(42)
First, regarding one of the factors initially invoked to explain it, namely increased mutation rates resulting from the lack of key repairing enzymes, as discussed above it has weak support given that one of the most relevant pathways, that is, the one responsible of correcting mismatches, seems to be active in Oikopleura, and most of such gene losses did not take place in Ciona.
XRCC3 is a key DNA repair protein involved in base excision repair [ 29] and is involved in repairing the alterations caused by many DNA damaging agents.
Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair enzyme involved in both base excision repair (BER) and nucleotide incision repair (NIR) pathways.
Mutations in the key DNA repair genes result in an impaired recognition system and an inefficient repair of DNA damage, which accelerates the aging of the organism, leading to age-related disruptions in cellular and tissue functions.
Recruitment of key HR repair proteins to the site of DNA damage, as well as HR repair capacity was compromised upon HDACi treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com