Sentence examples for key proliferation from inspiring English sources

In addition, Ki67 is a key proliferation marker for calculating breast cancer recurrence score in the Oncotype-DX assay [ 19].

The mechanisms of ATO-mediated tumor cell responses include inactivation of key proliferation and survival pathways including the hedgehog, MAP kinase, NfκB and PI3K/AKT signaling pathways [ 5].

The effects of G-CSF on proliferation of GI carcinoma cells are not surprising given the activation of such key proliferation pathways.

In order to improve the outcomes for patients, advances in understanding of the pathophysiology of breast cancer combined with the identification of proteins and molecular pathways that affect key proliferation and survival mechanisms are needed.

In tumors harboring the V600E mutation, BRAF seems to be the key proliferation driver [ 37]; thus, vemurafenib causes dramatic tumor shrinkage in patients with V600E-mutated tumors but not in tumors wild-type for BRAF [ 38].

However, the gold standard for cell culture characterization remains cell density as it enables the calculation of key proliferation and metabolic rates (Abaci et al., 2010; Cochran et al., 2006), though its determination is often limited to end-point destructive assays.

Together, these findings indicate that miR-15 and miR-16 play broad roles in oncogenesis, affecting key cell proliferation and invasion systems.

One disadvantage of the hallmarks framework is that it runs the risk of key concept proliferation, as the ever-growing base of knowledge implicates new processes in oncogenesis or as entirely different mechanisms are discovered.

Using a cDNA microarray, we identified that SSTR1 exerted its tumour suppressive function through inhibiting the key cell proliferation and apoptosis regulators, inducing MDM2, AKT, PI3KR1, BCL-XL and MET.

However modulation of these molecules by a variety of mechanisms (e.g., gene therapy, antisense oligonucleotides, small interfering RNA) may enhance the efficacy of radiation therapy by modifying the activity of these key cell proliferation and survival pathways.

The US's inability to back threats with tangible actions in response to Iran's nuclear trickery has cost America a key non-proliferation tool and suggested the waning of a global power.