Nevertheless, lower pol-prim levels or weakened origin association that approaches below a minimal threshold may alter the temporal and spatial pattern of origin firing in S phase, as was shown for the key origin firing factors Cdc45 and Sld3 (Mantiero et al., 2011; Tanaka et al., 2011).
Besides, factors involved in the establishment of origin timing such as histone deacetylation induce local modifications in these key origin features, leading to a more open origin conformation.
But why choose a little-known symposium in Maryland, or hospitals in New York and Pennsylvania, as key origin points for the current renderings of 'self-harm'?
Despite the fact that early and late specific chromatin patterns are conserved in rpd3Δ mutants, the remodelling of key origin features such as the NDR and -1 /+1 nucleosomes leads to a more open conformation.
A harmful host response to bacterial infection is believed to be the key origin of sepsis, in which invading bacteria and their products such as lipopolysaccharide (LPS) are potent activators of the inflammatory reaction [ 3].
To begin to test this, we examined replication on pBS/ARS1WTA containing a wild-type ARS1 and pBS/ARS1A−B2−, the same plasmid in which two key origin elements (A and B2) have been replaced with an XhoI linker (Marahrens & Stillman, 1992; Remus et al, 2009).
A shallow shadow box will hold keys nicely on display and provide you with room to write or type the key origin.
Those low-key origins are long forgotten now as we watch armoured vehicles sky-dive into Azerbaijan, million-dollar roadsters leap from the windows of glittering skyscrapers in Abu Dhabi, and a large section of Los Angeles gets blown up in a battle between hot-rods and helicopters.
It also from an electronic effect angle sheds light on the nature of the conventional lock-and-key origin of high enantioselection and carries the message that, to design a good catalyst (the key), rather than focusing on the rigidity, bulkiness or C2-symmetry of the catalyst, one should focus more on the helical character of the substrate (the lock) with which the catalyst will interact.
was the starting point for Key's origins, and was the first time the principal Key team was formed.
