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Aspirational young women were a key niche in this strategy, which was very successful.
In practice, these volunteers fill a key niche: Hospice uses team-based care to provide comfort for people at the end of life and support for family members.
HFSCs share their location with another skin stem cell population, the melanocyte stem cells, and it was shown that TGF-β signaling is one of the key niche factors regulating the maintenance of melanocyte stem cells [157].
Alternatively, a recent report by Ding et al (26) describes a population of LepRb+ perivascular/perisinusodal cells within the bone marrow that provide a key niche component in maintaining hematopoietic stem cells; the role of LepRb signaling in these cells also remains undefined, however.
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In this context, determining the key niche-indicators, and subsequently the bacterial responses to these, are fundamental goals of pathogen functional genomics.
Equally, ToeSox appears to be exploiting her yoga connection – and body – to appeal to a key consumer niche for its product.
Furthermore, a physiological hypoxic condition is also known to be one of the key beneficial niche features for stem cells in vivo.
46 Population interaction models suggested that ICU was a key environmental niche for CC30, consistent with a highly drug resistance phenotype.
The widespread conservation of the Tde toxin and Tdi immunity across bacterial genomes suggests that an appropriate combination of a functional T6SS and a broad toxin repertoire is key to niche colonization within a polymicrobial environment.
This approach enables further dissection of key cellular and niche components involved in thymic epithelial stem cell maintenance and T cell production.
For this new breed of problem-led organizations, curating a broad network of experts, stakeholders, entrepreneurs and enthusiasts is key to matching niche but critical problems with rogue, diverse pieces of information which come together to solve them.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com