The REL gene, a key modulator of the NFκB pathway, is associated with PsA but the allele conferring risk to RA is protective in PsA suggesting that there are fundamental differences in the aetiological mechanisms underlying these two types of inflammatory arthritis.
Johnson, S. C., Rabinovitch, P. S. & Kaeberlein, M. mTOR is a key modulator of ageing and age-related disease.
Binderman, I., Gadban, N. & Yaffe, A. Extracellular ATP is a key modulator of alveolar bone loss in periodontitis.
Meanwhile, PTEN expression was downregulated, suggesting it may not be a key modulator of Akt phosphorylation (B,E).
The cytokine TGF-beta1 is a key modulator of immune responses that is increased in the brain in AD.
Collectively, these results highlight the role of PRMT5 as a key modulator of OPCs early development and differentiation, but not as a regulator of physiological proliferation.
Kelly, T., Huang, Y., Simms, A. E. & Mazur, A. Fibroblast activation protein-α: a key modulator of the microenvironment in multiple pathologies.
Collectively, our experimental results, corroborated with patient data, establish the miR-564/AKT2-GNA12-GYS1-SRF network as a key modulator of cell proliferation, EMT migration and invasion in breast cancer.
Here, we identify the vitamin D receptor (VDR) as a key modulator of inflammation and β cell survival.
Consistent with their higher density, pericytes appear to act as a key modulator of the neurovascular unit in the brain[123].
