The JPDA* is the improved version of JPDA with one key modification: for each set of detected targets and set of measurements, only the best joint association event is chosen to be used in the calculation of the measurement-to-target probabilities.
During PC progression, PTEN inactivation is an established key modification for the emergence of androgen refractoriness [ 44].
However, in this study, the phosphorylation of FoxO1 may not be the key modification for ERK1/2-mediated FoxO1 degradation.
SARR was derived from the United Kingdom Institute of Hydrology (UKIH) method with several key modifications to adapt it for small watersheds (<50 km2).
Ff-hiPSCs were differentiated into blood cells as described previously30 with some key modifications.
Congruent with diminished protein-chaperoning capacity following nutrient deprivations, protein Lys48 polyubiquitination, a key modification targeting proteins for proteasomal degradation and a surrogate indicator of protein misfolding (Pickart & Eddins, 2004), was aggravated under both basal and heat shock conditions (Fig 4E and F).
N-linked glycosylation is a key posttranslational modification for proteins that are essential mediators in bacterial recognition, proteolytic resistance, intracellular signaling, and antigen binding and presentation (Marth and Grewal 2008; Dallas et al. 2012).
Among these, the prolyl-isomerase Pin1, a phospho-specific transducer of post-translational modifications for numerous key signaling molecules, surely is one of the most interesting.
We show that cChIP-seq is highly successful at generating data on 10,000 cells for several key histone modifications, and requires little modification to a standard ChIP-seq protocol.
Forty-four Democrats joined 207 Republicans in voting to renew key provisions of the act, with some modifications, for four years.
