Sentence examples for key mode of action from inspiring English sources

A key mode of action that links formaldehyde exposure to cancer involves damage to DNA (Lu et al. 2011; NTP 2011).

Both selective and broad caspase inhibitors have been reported to improve survival in sepsis models, and inhibition of lymphocyte apoptosis has been suggested as the key mode of action of these compounds [ 20, 24- 27].

The key mode of action events have been described as: (1) metabolism of benzene to benzene oxide, (2) interaction of this metabolite with critical bone marrow cells, (3) initiated bone marrow cells, (4) clonal proliferation of initiated cells and (5) development of leukemia (Meek & Klaunig, 2010).

Induction of p27 has previously been described as one of the key modes of action of HER2-targeting antibodies in breast cancer (Le et al, 2005b), with an increase thought to cause proliferating cells to exit the cell cycle and induce apoptosis.

These screens rely on key modes of action that are central to the most common mechanisms of DILI, e.g. ROS generation and GSH depletion as occurs during oxidative stress, mitochondrial membrane potential change as occurs during mitochondrial injury, inhibition of BSEP as occurs during drug-induced intrahepatic cholestasis (Boelsterli 2003).

As a matter of fact, current concepts suggest that inhibiting T cell co-stimulation is the key mode of CTLA-4 action.

As explained in the introductory paper of this series (Julien et al., 2009), a systematic analysis of individual Key Events along the mode-of-action pathway between intake and effect of concern may contribute new insight with regard to dose-response, biological thresholds, and safe intake levels.

The present case example used a vitamin for which there is a relatively good understanding of mode-of-action and Key Events.

One key requirement for modern pharmaceuticals is a specific mode-of-action with little or no side-effects in vivo.

Mode-of-action models strengthen science in two important ways.

Subsequently, mode-of-action and pharmacokinetic information were incorporated.