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Several probabilistic data processing techniques are explored in order to estimate two key localisation parameters from a single radar signal, namely along-track position and across-track position, with respect to the gate road structures.
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The key to solving the localisation problem is to optimally use and fuse all useful sources of information available to the mobile platform.
In addition, efficient substrate channelling and lipid synthesis could depend on specific endoplasmic reticulum subdomain localisation for key endogenous enzymes, and this organization could be compromised in heterologous systems.
There are several lines of evidence which indicate that sub-cellular localisation is key determinant of the antiviral activity of Mx proteins.
Notch regulates ciliary architecture and localisation of key Shh pathway components, thus sensitising cells to Shh.
Thus, localisation is key for CLU physiology, explaining the wide range of effects in cell survival and transformation.
In conclusion, KNPA2 nuclear expression is association aggressive features in BC, and this may be related to aberrant cytoplasmic localisation of key nuclear proteins.
Experimental software allowed registration of the centres of the hip, knee and ankle following a series of prescribed lower limb movements and localisation of key bony landmarks.
These data identify Notch signalling as a novel modulator of Shh signalling that acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery.
Taken together, these data demonstrate that Notch activity has a conserved, Shh-independent and significant effect upon localisation of key components of the Shh pathway within primary cilia, functioning at the level of the Ptch1/Smo interface to modulate ciliary localisation of these two signalling components.
To our knowledge, this is the first study to investigate the role of KPNA2 in the subcellular localisation of key proteins related to BC development and progression with particular emphasis on DDR proteins using a large series including different molecular classes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com