Sentence examples for key lesion from inspiring English sources
31 Hepatocyte ballooning is now widely recognised as the key lesion for distinguishing NASH from simple steatosis.
In the latter, the extent of leukocyte adhesion is predictive of the degree of subsequent neointimal hyperplasia, which is the key lesion of ISR.
Mitochondrial CyP-D (cyclophilin-D) catalyses formation of the PT (permeability transition) pore, a key lesion in the pathogenesis of I/R (ischaemia/reperfusion) injury.
Indeed, although DNA interstrand cross-links typically account for only 1 5% to the total adduct burden, they are believed to be the key lesion in the mechanism of action of nitrogen mustards and related agents.
When suitable antibodies are available, the immunochemical approach enables one to analyze various types of adducts separately, and to discriminate between irrelevant (e.g., quickly repairable) and relevant lesions (key lesions) with respect to biological end points such as mutation induction and cancer.
It has been suggested that the key lesions begin to develop a considerable time prior to the appearance of clinical symptoms [ 13], but based on our results there do seem to be some subjects who can tolerate substantial amounts of pathology.
However, c-Myc appears to be activated at the earliest phases in prostatic intraepithelial neoplasia, contributing to disease initiation and progression, and c-Myc is a key precursor lesion for invasive prostatic adenocarcinoma.
Based on this, most of modern oncology drug discovery efforts are targeting to the etiology of cancer by seeking the key genetic lesions which are driving the tumorigenesis.
Firstly, it should yield mouse models that represent the human disease, i.e. de novo tumor development should be driven by key genetic lesions induced in the relevant target tissue in phenotypically wild-type hosts, and display the typical clinical stages of tumor progression in patients.
Weakening of ECM structure plays a key role in lesion rupture, the major cause of heart attacks and strokes.
Further, it supports the concept that, once infection is established, the host inflammatory response is a key determinant of lesion severity in the urinary tract.
