For example, does the total number of keys on a piano provide the complexity to create music, or is it the combinatorial fashion in which the keys are activated by the pianist's fingers.
However, it is still relatively unclear how this key pathway is activated and how Wnt/β-catenin signaling affects specific cells and stages of the regenerative process.
In response to oxidative stress, p53, a key regulator, is activated and transactivates its target genes through binding upon specific DNA sequences in their promoter region (Gambino et al., 2013).
A key protein that is activated upon PIPn binding is Akt, which then plays important roles in regulating the cell cycle, and is thus aberrant in disease.
The key, how Bax is activated, represents an important and largely open question, which is of general interest in apoptosis research.
Eps8 is an actin bundling and capping protein whose capping activity is inhibited by Erk, a key MAP kinase that is activated by oncogenic signaling.
The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch that is activated by a myriad of cell surface receptors to promote cancer cell migration/invasion and survival.
It is a key metabolic regulator that is activated under stress conditions.
P53 is a key transcription factor that is activated in response to various cellular stresses.
Sgk1, a key mediator of fibrosis, is activated by a positive GRE.
