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An excerpt that describes Gerasim's key interaction with Ivan Ilych is provided.
B) The space available for a hydrogen bond-accepting atom forming a key interaction with Gly 253 (red-dotted sphere).
Other shared but non-residue specific interactions include the anchoring hydrogen bonds at the hinge, and a key interaction with a main chain carbonyl group.
Another key interaction with the guanine moiety of cGMP occurs at the flexible side chain of Arg297.
This study provides an additional mechanistic insight into how FREM1 regulates adhesion of the developing epidermis and identifies a key interaction with the PDGFC growth factor.
Furthermore, the structures showed that the fragment portion of all the compounds maintained the key interaction with Glu396 despite changes in the lysine or larger peptide positioning, highlighting the effectiveness of fragments as anchors in key PPI hot spots.
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We further identified positively charged surface residues by KS mutagenesis, which mediates key interactions with the negatively charged ACP surface.
Molecular modeling studies explain how these ROS1 kinase inhibitors revealed effectively the key interactions with ROS1 ATP binding site.
Recent evidence indicates that our immune and inflammatory systems are trained and educated in our gut, through key interactions with gut bacteria.
Structural information obtained by Jia et al. revealed that residues Y320 and D327 in the cytoplasmic tail of MHC-I bridge key interactions with Nef and AP-1, supporting Nef-dependent downregulation of MHC-I10.
As the ADHBA moiety of 3 and 4 makes key interactions with the target proteins FabF and FabH9,10, the ADHBSH moieties of 1 and 2 likely bind in a similar manner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com