Exact(18)
Accumulating evidence indicates that Runx2 is the key integrator, whereas Hh is a possible modulator, miRNAs are regulators, and β-catenin is a mediator/regulator within the extensive intracellular network.
It is also a key integrator of circadian entrainment to light, in part regulated by pituitary adenylate cyclase-activating peptide (PACAP).
Furthermore, disruption of MyD88 signaling, a key integrator of multiple TLRs prevented the development of colorectal tumors in Il10−/− mice.
Therefore, we speculate that OsCYP2 may function as a key integrator in response to multiple stresses.
Many reports have demonstrated that PGC-1 α is a key integrator of neuromuscular activity in skeletal muscle.
Thus, Art may uniquely function as a key integrator of DNA damage signals, cellular response and DNA repair.
Similar(42)
Critically, the sterol regulatory binding protein 1 and its targets are key integrators of antibody and T follicular cell responses.
Interestingly, the C. elegans genome does not express known homologs of rel-type transcription factors, suggesting that GATA factors may function as key integrators of cellular stressors and immune responses.
Some enrichment on signaling pathways can reveal key integrators that coordinately drive toward cell decisions.
The STAND NTPases are predicted to interact with different types of effector/signaling components and function as key integrators of stress and nutrient availability signals.
Both ERF1 and ORA59 appear to be the key integrators of the ET -and JA-signaling pathways (Pieterse et al., 2009).
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