Sentence examples for key initiators from inspiring English sources
Caspase-like proteases are key initiators and executioners of programmed cell death (PCD), which is initiated by environmental stimuli and manifests in organisms ranging from unicellular microbes to higher eukaryotes.
Consistent with these results, western blotting of HCC cells treated with the compounds resulted in molecular changes for cell cycle proteins, where p21 levels were increased independent of p53 and the levels of the key initiators of mitosis Cyclin B1 and CDK1 were shown to decrease upon treatment.
Platelets are key initiators of hemostatic mechanisms that repair injury to the vasculature.
Indeed, DSBs are thought to be the key initiators of homologous exchange.
One of the key initiators in mitochondrially mediated apoptosis is cytochrome c, which, on release from mitochondria, causes caspase activation.
Hypoxia and the subsequent stabilization of hypoxia inducible factor-1 (HIF-1) is one of the key initiators of (tumor- angiogenesis as reviewed by Liao and Jonson [ 57].
Most agree that inflammation is a key initiator and driver of the disease, but what initial insult or factors drive this and why it does not resolve is unclear.
The High Mobility Group Box 1 (HMGB1)/Toll-like receptor 4 axis is a key initiator of neuroinflammation following brain injuries leading to epilepsy, and its activation contributes to seizure mechanisms in animal models.
Cyt c is essential for mitochondrial electron transfer and is a key initiator of apoptosis in mammalian cells [28].
The serine/threonine kinase ULK1, like its yeast homologue Atg1, is a key initiator of autophagy that is negatively regulated by the mTOR kinase.
Since PLA2 serves as the first rate-limiting step leading to eicosanoid formation, these results suggest that TGM2 may be a key initiator of the airway inflammatory cascade in asthma.
