At the initial stage of MFs differentiation, TGF- β1 is the key-inducing factor.
Instead, we find references to families of approaches (developmental genetics, experimental embryology, cell biology, and molecular biology) or catalogues of "key molecular components" (transcription factor families, inducing factor families, cytoskeleton or cell adhesion molecules, and extracellular matrix components).
Mitochondrial permeabilization results in the release of key proapoptotic proteins cytochrome c, apoptosis inducing factor (AIF), endonuclease (endo) G and Smac/Diablo from the mitochondria to the cytosol [3], [5], [10], [11], [12].
The work, and ultimately identifying the key trauma-inducing factors, has a long way to go, Camarillo said, and could benefit from stricter guidelines.
A key mediator of apoptosis, mitochondrial function, and cell survival is apoptosis inducing factor (AIF).
High alkalinity and calcium ions are key factors inducing the agglomeration of GO in cement system.
Finally, in the PMCAO model, NAP provided a significant protection against neuronal damage associated with stroke by inhibiting key factors inducing apoptosis of neuronal cells (Leker et al., 2002).
The association of TRAF2 and RIPK1 activates MAPK pathways, which in turn lead to the activation of NFκB, a key transcription factor inducing many target genes, including many components of the inflammatory and cell survival responses [37].
Thus, NF-κB is the key transcription factor inducing inflammatory response and a promising target for anti-inflammation [ 39, 40].
Further analysis of emm/M type distribution, a key virulence factor inducing immunologic memory, will assist in assessment of the potential effect of vaccines currently under development.
