Our goals were to; 1/ develop a sequencing methodology which efficiently circumvents the difficulties associated with A. phagocytophilum isolation and culture; 2/ describe the first genome of a bovine strain; and 3/ compare it with available genomes, in order to both explore key genomic features at the species level, and to identify candidate genes that could be specific to bovine strains.
Genome analysis of BFo1 reveals a lack of key genomic signatures that are commensurate with pathogenicity within this genus, consistent with a commensal life-style for BFo1.
They cumulatively represent more than 400 million years of independent evolution (MRCA 200 mya [ 16]), and embody the key genomic and life-history characteristics of interest for fern genome sequencing.
The hubs lacked disease-associated SNPs, constituted a nonrandomly interconnected core of key cellular functions, and exhibited lethality in mouse mutants, supporting an evolutionary selection that favored the nonrandom spatial clustering of the least-evolving key genomic domains against random genetic or transcriptional errors in the genome.
Genome-wide scans on patients with psoriasis have identified a number of key genomic regions linked to Type I disease.
These studies reveal key genomic and epigenetic factors that support de novo centromere formation in eukaryotes.
For Kristen Hawkes, a behavioral ecologist at the University of Utah in Salt Lake City whose field studies led to the grandmother hypothesis in 1998, the findings provide key genomic evidence that has been lacking in the field.
Ovarian cancer is both heterogeneous and cytogenetically complex making it difficult to decipher the key genomic regions affected by CNA.
Having defined regression equations between the key genomic parameters, we applied these models to P. taeda, an important but incompletely sequenced species.
We also carried out detailed examination of transcripts from the key genomic regions of the MHC and the Epidermal Differentiation Complex (EDC).
Considering that studies on nucleolar dominance were focused in silenced NORs behaviour [11], [12], information on the transcriptional level and chromatin organization of dominant NORs is still sparse and needed for the growing understanding of the dynamic behaviour of these key genomic domains.
